1,300 BC to 1000 AD - Olmecs occupy area around Tres Zapotes.
500-1000 Teotihuacan related peoples settle in area. 1465? - Aztec Motecuhzoma Ilhuicamina (1440-1469) conquers the south central Veracruz area.
1522 - Hernán Cortés arrives at Totógatl, forerunner of Santiago Tuxtla. (disputed) 1523 - First sugarcane planted near Uvero 1525 - Foundation of Santiago Tuxtla. 1529 - Hernán Cortés is awarded the area as part of the Marquesado del Valle de Oaxaca. 1523 - First sugarcane plantations in Los Tuxtlas
1530 - San Martin Volcano erupts. (disputed) 1580 - the estancia of Santiago Tuxtla is mentioned 1664 - Volcano San Martin eruption evacuates many Santiago Tuxtla residents to San Andres Tuxtla.
1718 - San Andres becomes a pueblo, separating it from Santiago. 1793 - San Martin Volcano erupts.
1825 - mentions Canton de Santiago Tuxtla as part of Acayucan. 1826 - San Andres Tuxtla secedes from Santiago Tuxtla. 1833 - Cholera wipes out half the population. 1950 - Santiago Tuxtlas receives the title "ciudad" (city) 1953 - The federal highway is paved. 1974 - The city is officially declared "Ciudad Colonial" (colonial city). 1979 - San Martin Volcano is declared a national reserve 1998 - The Biosphere Reserve of Los Tuxtlas is created 2008 - First modern bank opened.