500-1000 +/- Large Teotihuacan related settlements near Matacapan & Belzoapan, suburbs of San Andrés city.
1529 - Hernan Cortes is awarded the area as part of the Marquesado del Valle de Oaxaca. 1530 - San Martin Tuxtla Volcano erupts. (disputed) 1530 - Tzacoalco (forerunner of San Andres) is founded (disputed) by natives from the nearby community of Ixtlan fleeing volcanic eruptions. 1580 - Tzacaoalco is mentioned as San Andrés Tzacoalco by the mayor of Tlacotalpan. 1650 ?The name of the city is now officially San Andrés Tuxtla 1664 - Volcanic eruption evacuates many Santiago Tuxtla residents to San Andrés.
1718 - San Andres becomes a pueblo 1793 - San Martin Tuxtla Volcano erupts.
1826 - San Andres Tuxtla secedes from Santiago Tuxtla and forms its own Canton (now municipio) 1830 - The city of San Andres Tuxtla is declared villa (town). 1833 - Cholera epidemic decimates the city. 1882 - Telegraph service initiated 1893 - San Andres Tuxtla is named ciudad (city).
1916 -City hall is burned during revolutionary upheavals and all archives detroyed. 1913 - First railroad train arrives in San Andres Tuxtla. 1932 - Municipio is renamed Los Tuxtlas. 1938 - Municipio is renamed San Andres Tuxtla. 1953 - The carretera federal is paved. 1979 - San Martin Tuxtla Volcano is declared a national reserve. 1992 - Last railroad train leaves San Andres Tuxtla. 1998 - The Reserva de la Biosfera Los Tuxtlas is created. 2005 - First modern department store opens in San Andrés city (Soriana).